EFFECT OF INTRAOVARIAN PRP ON THE QUALITY AND QUANTITY OF OOCYTES, AND FERTILIZATION RATE

Abstract

Infertility is on a rise in the current scenario. There are various factors that contribute to infertility. One of them is ovarian dysfunction. Ovarian dysfunction includes PCOS, ovarian aging, etc. Ovarian aging is a physiological process wherein the antral follicle count decreases thereby leading to decrease in the quantity and quality of the oocytes and causing menopause in females. Premature ovarian ageing is increasing in females who are below the menopausal age. In order to restore the ovarian reserve, one of the therapeutic treatments that is being used is autologous platelet rich plasma therapy. The platelets are rich in growth factors, integrins, chemokines and cytokines which promote cell division and differentiation, angiogenesis, cell migration, tissue repair and restoration. The platelets are extracted from the whole blood and are then injected into ovaries. Following the injection, the stimulation is started from the next cycle and the IVF procedure is performed. The objective of our study is to see the effect of PRP on the quality and quantity of oocytes, fertilization rate and implantation rate and to compare it with IVF cycle done prior to PRP. It was observed that there was an increase in the quality and quantity of oocytes and fertilization rate in post PRP IVF cycles compared to Pre cycles. The significance level of our study is above 95% hence proving the data statistically significant.